Directed Transport of CRP Across In Vitro Models of the Blood-Saliva Barrier Strengthens the Feasibility of Salivary CRP as Biomarker for Neonatal Sepsis

C-reactive protein (CRP) is a commonly used serum biomarker for detecting sepsis in neonates. After the onset of sepsis, serial measurements are necessary to monitor disease progression; therefore, non-invasive detection method beneficial neonatal well-being. While some studies have shown correlation between and salivary CRP levels septic neonates, causal link behind this remains unclear. To investigate relationship, was examined saliva samples from 18 neonates compared with 22 healthy measured blood concentrations varied individually, observed over time. clarify presence active transport across blood–salivary barrier (BSB), were performed using vitro models oral mucosa submandibular gland epithelium. The results showed enhanced toward both models, supporting clinical relevance as biomarker. Furthermore, regulated expression receptor advanced glycation end products (RAGE) addition soluble RAGE during indicated RAGE-dependent process saliva.